Furthermore, bile acids have also been shown to regulate the interaction in the gut-brain axis (Gan et al., 2024a).Some studies have indicated an increasing trend in the abundance of Ruminococcus in the P.g -treated mouse group (Kato et al., 2018), and certain Ruminococcus species, such as Ruminococcus torques ( R.t ), possess direct vitamin D hydroxylation potential (Yamamoto and Jrgensen, 2019)
Critically, this redox adaptation is a key mechanism of resistance to radiotherapy and many chemotherapeutic agents, such as cisplatin and doxorubicin, which depend on generating oxidative damage to exert their cytotoxic effects [33]
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Deng, R., Xie, X., Vendrell, M., Chang, Y
Acknowledgements This work was supported by the National Natural Science Foundation of China (81902422, 82403008), the China Postdoctoral Science Foundation (2024M762749), the Natural Science Foundation of Jiangsu Province (BK20231245, BK20250559), the program of Jiangsu Traditional Chinese Medicine Science and Technology Development (No.MS2024140), the key program of Jiangsu Provincial Health Commission (K2025009), Social Development Program of Yangzhou Science and Technology Bureau (No.YZ2025094), Yangzhou City Basic Research Program (Joint Special Project) - Health and Wellness Category (2024-2-08, 2025-2-08, and 2025-3-15), Natural Science Foundation of Minhang District (2025MHZ052)